Medications associated with prolonged QT / long QT

November 23rd, 2009
by reuben in arrhythmia

16 2123

JAMA 289:16 2123

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Responses to “Medications associated with prolonged QT / long QT”

  1. Here’s another (searchable) list which also includes CYP450-inhibiting agents.

    Medications That Cause QT Interval Prolongation and/or Torsades de Pointes

    Amiodarone
    Amitriptyline
    Arsenic trioxide
    Azithromycin
    Bepridil
    Chlorpromazine
    Clarithromycin
    Desipramine
    Disopyramide
    Domperidone
    Doxepin
    Droperidol
    Enflurane
    Erythromycin
    Fluconazole
    Gatifloxicin
    Haloperidol
    Halothane
    Ibutilide
    Imipramine
    Indapamide
    Isoflurane
    Itraconazole
    Ketoconazole
    Levofloxacin
    Levomethadyl
    Mesoridazine
    Methadone
    Moxifloxacin
    Nortriptyline
    Pentamidine
    Pimozide
    Procainamide
    Quetiapine
    Quinidine
    Risperidone
    Sotalol
    Sparfloxacin
    Tacrolimus
    Tamoxifen
    Televancin
    Thioridazine
    Trimethoprim-sulfamethoxazole
    Voricollazole

    Substrates of CYP450 3A4

    Alprazolam
    Amlodipine
    Astemizole
    Atorvastatin
    Buspirone
    Cafergot
    Chlorpheniramine
    Clarithromycin
    Cocaine
    Cyclosporine
    Dapsone
    Dextromethorphan
    Diazepam
    Diltiazem
    Erythromycin
    Estradiol
    Felodipine
    Haloperidol
    Hydrocortisone
    Indinavir
    Irinotecan
    LAAM
    Lidocaine
    Lovastatin
    Methadone
    Midazolam
    Nelfinavir
    Nifedipine
    Nisoldipine
    Ondansetron
    Paclitaxel
    Pimozide
    Progesterone
    Propranolol
    Quinidine
    Quinine
    Ritonavir
    Salmeterol
    Saquinavir
    Sildenafil
    Simvastatin
    Sirolimus
    Tacrolimus
    Tamoxifen
    Testosterone
    Trazodone
    Triazolam
    Verapamil
    Vincristine
    Zaleplon
    Zolpidem

    Inhibitors of CYP450 3A4

    Cimetidine
    Ciprofloxacin
    Clarithromycin
    Delaviridine
    DiItiazem
    Erythromycin
    Fluconazole
    Fluvoxamine
    Grapefruit juice
    lndinavir
    Itraconazole
    Ketoconazole
    Mifepristone
    Nefazodone
    Nelfinavir
    Ritonavir
    Saquinavir
    Verapamil
    Voriconazole

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