When the patient can’t breathe, and you can’t think: The emergency department life-threatening asthma flowsheet

December 14th, 2011

by reuben in .dyspnea, asthma
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Another case report demonstrates the utility of dissociative-dose ketamine in the deteriorating asthmatic. Life-threatening asthma is uncommon and difficult to study; we may never have better evidence and it’s time to add ketamine to the kitchen sink. This flowsheet incorporates ketamine into a stepwise approach to the severe asthmatic for the emergency clinician who may not remember drip rates and vent settings when her own heart rate is 140.




Management of Life-Threatening Asthma in the Emergency Department (pdf)

Management of Life-Threatening Asthma in the Emergency Department (jpg)

Dexmedetomidine has found its home in the ED: Pediatric painless procedures

November 10th, 2011

by reuben in PSA & analgesia
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Dexmedetomidine (trade name Precedex) is an alpha-2 receptor agonist, similar to clonidine. Whereas clonidine provides a robust decrease in blood pressure with mild sedation, dexmedetomidine provides robust sedation with a mild decrease in blood pressure. It does not depress airway reflexes or respiration. It has a variety of potential uses in the emergency department, including procedural sedation, the facilitation of awake intubation or noninvasive ventilation, and the treatment of alcohol withdrawal. For these indications, however, we have agents that are at least as good, familiar, and a hell of a lot cheaper.

Sedation for painless procedures in children is the scenario that may push dexmedetomidine into the emergency physician’s toolkit. Kids who require sedation for CT or MR imaging would ideally be managed without placing an IV (nix etomidate), using an agent that does not cause significant cardiorespiratory depression (nix barbiturates), is otherwise safe (nix chloral hydrate, which is also unpredictable, untitratable, and lasts forever), and reliably causes kids to be still (nix ketamine).

This case series reports on 65 consecutive children sedated for CT or MRI with intramuscular dexmedetomidine, administered either once or twice at a dose of 1-4 mcg/kg, the exact dose left to provider discretion, to achieve a target Ramsay score of 4 (asleep but briskly responsive to a light stimulus). 4 patients out of 65 required a second IM dose to achieve a Ramsay score of 4. Once Ramsay 4 was achieved, no other agents were given for the duration of the procedure. The mean dose was about 2.5 mcg/kg.

All 65 children successfully completed the study. Though 9 out of 65 patients developed transient hypotension, there were no adverse events that required intervention. 65 patients is not enough to conclusively demonstrate safety, but 100% efficacy is hard to beat, and I suspect the safety profile will stand up in larger series.

Average time to sedation was 13 minutes. The average time from the end of the study to recovery was 22 minutes in the MRI group and 17 minutes in the CT group, with wide confidence intervals, i.e. there was no difference in recovery times. Since MRI is significantly longer than CT, and no sedatives were administered after the initial dose, how can this be?

Dexmedetomidine causes a different type of sedation than what we’re used to. It’s not a CNS depressant in the typical sense, it’s a powerful sympatholytic. Patients sedated with with dexmedetomidine will wake up with minimal stimulation, but when that stimulation is removed, they gently drift off to sleep. This is not a useful feature when trying to facilitate awake intubation, but it’s perfect for getting a 3 year old through the CT scanner.

 

Mason KP, Lubisch NB, Robinson F, Roskos R. Intramuscular dexmedetomidine sedation for pediatric MRI and CT. American Journal of Roentgenology 2011 Sep;197(3):720-5.

The Precipitants of Everything

October 2nd, 2011

by reuben in heuristic
2 Comments

 

A common mistake made by junior emergency physicians (and sometimes not junior emergency physicians) is to identify a problem and address it without considering its precipitant. Recognizing that the patient’s symptoms are due to an exacerbation of CHF, asthma, or COPD, DKA, seizure (the med student thought it was syncope but you know better), atrial fibrillation, hypoglycemia, dehydration, hepatic encephalopathy, uremia, or electrolyte disturbance: that’s fabulous. Knowing how to treat these conditions: phenomenal. But if you really want to impress the opposite sex, or the same sex, or whatever you’re into, figure out why the patient is having this problem, now. Fortunately, the same things cause most of the common afflictions of ED patients. So here they are, the precipitants of everything:

 

medication changes and, especially, noncompliance

recreational intoxicants and other lifestyle choices

withdrawal (but why was this patient unable to get his fix today? there may be a further precipitant)

infection (lungs, urine, skin, CNS, abdomen, indwelling catheters and devices, soft tissue/bone)

ischemia (heart, brain, bowel)

arrhythmia

pulmonary embolism

thyrotoxicosis or hypothyroidism

occult trauma / abuse / neglect

bleeding (GI bleed, vaginal bleed, urologic bleed, retroperitoneal bleed, abdomen, thorax, thigh, street)

pregnancy (if there’s abdominal pain, bleeding, or syncope – don’t forget to rule out ectopic)

 

That doesn’t mean we ought to do ancillary testing to rule out these precipitants of everything; in most cases a directed history and physical is all you need. Just remember to ask the question, why is this patient having this problem, now?

The virtues and vices of emergency medicine

September 6th, 2011

by reuben in heuristic
1 Comment

 

 

{adapted from a lecture I give to first year med students, at the end of a two-week course where we teach them how to be an effective first responder in a variety of pre-hospital emergency scenarios.}


 

 

 

Emergency doctors staff emergency rooms. We see whatever comes in, as fast as it comes in. We are the front door of the hospital, and we never close our doors. The specialty is defined by several key characteristics, which are virtues or vices, depending on your perspective, and often they are both at the same time. So I’m going to present them as both at the same time, in a sort of pro-con format.

 

1. The undifferentiated patient

No other doctor routinely manages patients she knows nothing about. A typical emergency patient was found on the street in a coma. He could be minutes away from dying, or just really drunk and needs to sleep it off. We’ve got to figure it out without even knowing his name, much less his medical history or the events leading up to his present condition. Making the diagnosis is really fun.

However, Uncertainty is the currency of emergency medicine. We have to make important decisions with very little information. We are wrong a lot. Sometimes, when we’re wrong, people die. Learning to be comfortable with uncertainty is difficult.

 

2. Speed

Emergency physicians have to think fast and act fast.  It has been reported that emergency medicine has the highest decision density not just of any medical specialty but of any human endeavor. This is fantastic for people who have limited attention spans and require a lot of stimulation. It also makes shifts fly by; I routinely realize it’s time to start wrapping up and I feel like I just arrived.

However, when you work in the emergency room, you are working hard. It’s tiring.

 

3. Momentary care

Emergency physicians do not follow patients. When you’re off, you’re off. We do not carry pagers. Being off when you’re off is a big deal from a quality of life perspective – when your shift ends at six, and you make plans for eight, you’re going to be there, and you’re not going to get called away.

However, we don’t form relationships with patients, and the patients we do form relationships with are usually not the kind of patients you want to form relationships with. Emergency medicine can feel impersonal, and it’s harder to learn from your mistakes because the consequences of your mistakes often are not apparent until you’re no longer taking care of the patient. But mostly the problem is that we don’t get chocolates from our patients at holiday time.

 

4. Shiftwork

Scheduling for emergency docs is flexible – if I want a month off, I can just ask not to be put on the schedule for a month. Combine this flexibility with the momentary care aspect–that we don’t follow patients–and you can see how this makes for a kind of freedom that is pretty unique in medicine.

However, emergency clinicians work erratic hours, including nights. This is probably the biggest challenge for emerg docs. If you need a regular schedule to sleep right, this is not the speciality for you. The ED never closes, and so we work evenings, nights, weekends, and holidays. We take a lot of pride of being available whenever we are needed, but sometimes you can feel out of sync with the rest of the world.

 

5. The front door

We are the safety net for everyone and, health care reform aside, that’s not going to change anytime soon. The emergency department is on the ground floor, and when you work in the emergency department, you feel like you are connected to the community. You feel like you are helping people who really need help.

However, our workflow is dictated by whatever comes through the front doors, and this is entirely unpredictable. The emergency department is in a constant state of barely controlled chaos, and sometimes it’s uncontrolled chaos. Many of my patients are having the worst day of their lives. Many of my patients live on the margins of society and their average day is worse than the worst day of most people’s lives. It can be very challenging to take care of these patients.

 

6. Disease spectrum

You name it, we deal with it. No other specialty even comes close to the multiplicity of presentations and diagnoses that an emergency physician confronts in a single shift. You get to put your hand in a lot of cookie jars.

However, emergency physicians rely heavily on consultants. I spend a lot of time on the phone talking to people whom I’m giving work to, so they don’t really want to talk to me. Also, when I call a consultant, I’m talking to someone who knows more about what we’re talking about than I do. When I have a complex neurology problem, I call a neurologist and talk with her about neurology; when I have a complex dermatology problem, I call a dermatologist and speak with her about dermatology. And sometimes consultants can get really uppity and even condescending, especially the ones who never come down to the emergency department and see us reducing fractures, and defibrillating people in cardiac arrest, and delivering babies, and sewing up the laceration on the billionaire everyone’s heard of who’s lying one gurney over from the undocumented immigrant who also has a laceration and speaks a language no one’s heard of, and providing comfort care to the 96 year old taking her last few breaths, and intubating the nearly dead 10 day old with undiagnosed congenital heart disease. But constantly asking for help can be hard on the ego. You have to be comfortable not being the expert.

Intubate with the head of the bed elevated

August 20th, 2011

by reuben in airway
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semi fowlers position

 

In addition to improving laryngeal view, there is now evidence that elevating the head of the bed prolongs apneic desaturation time. This makes good sense, and the tradition of intubating patients in the supine position should be added to the long list of Things We’ve Been Doing Wrong All This Time. Using semi-fowlers position also probably reduces the risk of regurgitation/aspiration, and is strongly recommended for all patients being intubated for upper GI bleed. But make it your routine and you will benefit when that extra little bit of glottic view, those extra few seconds of apnea, and that extra bit of protection against regurgitation really matter. There is no downside.

 

Ramkumar 2011

Purpose Failed airway is the anesthesiologist’s nightmare. Although conventional preoxygenation can provide time, atelectasis occurs in the dependent areas of the lungs immediately after anesthetic induction. Therefore, alternatives such as positive end-expiratory pressure (PEEP) and head-up tilt during preoxygenation have been explored. We compared the conventional preoxygenation technique (group C) with 20° head-up tilt (group H) and 5 cmH2O PEEP (group P) in non-obese individuals for non-hypoxic apnea duration.

Methods A total of 45 patients were enrolled (15 in each group). After 5 min of preoxygenation, intubation was performed after induction of anesthesia with thiopentone and succinylcholine. After confirming the tracheal intubation by esophageal detector device and capnogram, all patients were administered vecuronium to maintain neuromuscular blockade and midazolam to prevent awareness. Post-induction, patients in all groups were left apneic in supine position with the tracheal tube exposed to atmosphere till the SpO2 dropped to 93% or 10 min of safe apnea was achieved.

Results The demographic data were comparable. Non-hypoxic apnea duration was higher with group H (452 ± 71 s) compared to group C (364 ± 83 s, P = 0.030). Group P did not show significant increase in the duration of non-hypoxic apnea (413 ± 86 s). There were no adverse outcomes or events.

Conclusions Preoxygenation is clinically and statistically more efficacious and by inference more efficient in the 20° head-up position than with conventional technique in non-obese healthy adults. Although application of 5 cmH2O PEEP provides longer duration of non-hypoxic apnea comparedto conventional technique, it is not statistically significant.

 

PMID 21293885

photo credit: http://goo.gl/yn2pq

Airway Control in the Massive Oral Bleed Patient

August 6th, 2011

by reuben in airway
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A middle aged gentleman presents with a basin filled with bright red blood. He’s choking, gagging and every ten seconds coughing up another huge mouthful. His daughter tells you that he has a base of tongue tumor that, 20 minutes ago, started bleeding. A lot.

Asphyxiation and exsanguination are both immediate concerns. He clearly needs to be intubated now. But how?

Awake technique is very unlikely to be successful; the patient is in extremis, blood pouring out of his mouth. He will need RSI. But you have at least two reasons to be concerned about RSI: 1. The huge amount of blood filling the oropharynx will obsure your view of the glottis. 2. The base of tongue tumor. Lord knows what you’ll see when you get in there.

The answer: Four Provider ED Double Setup.

Provider #1: Performs video laryngoscopy.

Provider #2: To the right of provider #1, performing suction.

Provider #3: To the left of provider #1, peforming suction.

Provider #4: At the patient’s side, prepared to perform cricothyrotomy.

For patients with massively bleeding oral lesions, bilateral suction, simultaneous with airway visualization, is necessary. Until recently, this was almost impossible, because only the operator can see the glottis during conventional laryngoscopy. Video laryngoscopy, however, has changed the rules. In addition to getting your eyes much closer to your target, with video laryngoscopy more than one person can participate in laryngoscopy at the same time. The magnitude of this advantage wasn’t apparent to me until a middle aged gentleman with basin filled with bright red blood presented himself in the process of both asyphyxiating and exsanguinating. I’ll bet there are other useful techniques made possible by projecting the airway onto the big screen for everyone to see. Laryngoscopy is now a team sport.

Thanks to Vishal Demla, Elizabeth Dei Rossi, Taylor Moran-Gates, Daniel Mindlin, and especially Eduardo Lacalle.

ketamine as a suicidality reversal agent

June 4th, 2011

by reuben in psychiatry
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Rapid-onset antidepressant? Hot damn.

I would prefer an ethanol antidote, or a cure for secondary gain, but this is a start.

Abstract: We examined the preliminary feasibility, tolerability and efficacy of single-dose, intravenous (i.v.) ketamine in depressed emergency department (ED) patients with suicide ideation (SI). Fourteen depressed ED patients with SI received a single i.v. bolus of ketamine (0.2 mg/kg) over 1–2 min. Patients were monitored for 4 h, then re-contacted daily for 10 d. Treatment response and time to remission were evaluated using the Montgomery–Asberg Depression Rating Scale (MADRS) and Kaplan–Meier survival analysis, respectively. Mean MADRS scores fell significantly from 40.4 (s.e.m.=1.8) at baseline to 11.5 (s.e.m.=2.2) at 240 min. Median time to MADRS score ≤10 was 80 min (interquartile range 0.67–24 h). SI scores (MADRS item 10) decreased significantly from 3.9 (s.e.m.=0.4) at baseline to 0.6 (s.e.m. =0.2) after 40 min post-administration; SI improvements were sustained over 10 d. These data provide preliminary, open-label support for the feasibility and efficacy of ketamine as a rapid-onset antidepressant in the ED.

Int J Neuropsychopharmacol. 2011 May 5:1-5. PMID: 21565879